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ACRP ACRP-CP Practice Exam Questions
ACRP Certified Professional Exam
Total Questions : 125
Update Date : July 06, 2026
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ACRP ACRP-CP Sample Question Answers
Question # 1After the site qualification visit report has been finalized, it must be:
A. Kept in the CRO/sponsor's trial master file.
B. Included in the PI's regulatory file.
C. Stored in the sponsor's budgets and contracts file.
D. Sent to the IRB/IEC for review and approval.
Question # 2
A representative from a regulatory authority shows up unannounced at a research site.After confirming their credentials, the representative requested to view the entire records,including identifiable information, from study XYZ that was closed out. Which of thefollowing should the site personnel do next?
A. Redact subject identification for privacy protection.
B. Deny the request until the sponsor approves.
C. Allow access to the entire records.
D. Consult with the IRB/IEC first.
Question # 3
AEs that occur between study visits of a clinical trial should be evaluated by the:
A. Subject's primary care physician
B. Principal Investigator
C. Medical monitor
D. Study pharmacovigilance physician
Question # 4
Who must be blinded in a double-blind study in order to prevent bias?
A. Pharmacist
B. Subject
C. Data entry staff
D. IRB/IEC
Question # 5
A study subject inadvertently disposed of IP medication bottles. The site should report thisto the:
A. Sponsor.
B. IRB/IEC.
C. Medical monitor.
D. Regulatory authority.
Question # 6
Which of the following documents is maintained by a PI to ensure compliance with sponsorrequirements?
A. Regulatory submission of protocol and accompanying documents to relevant regulatoryauthority.
B. A monitoring report that identifies deviation from the approved protocol.
C. A monitoring plan that is tailored to the specific human subject protection and dataintegrity risks of the trial.
D. Training records of site personnel on study protocol, and their study-related duties andfunctions.
Question # 7
A PI on a study is a regular member of the IRB/IEC. Which of the following statements isTRUE regarding their participation in the IRB/IEC discussion and deliberation?
A. They cannot be the PI on the clinical study due to conflict of interest.
B. They can attend the meeting and can vote/provide opinion on whether to approve thestudy.
C. They must recuse themselves from the meeting given their dual roles as IRB/IECmember and PI.
D. They can attend the meeting, but should not vote/provide opinion on whether to approvethe study.
Question # 8
After the completion or termination of a clinical trial, who should store the enrollment log?
A. PI
B. CRO
C. Sponsor
D. Regulatory authority
Question # 9
A double-blind randomized Phase III trial seeks to recruit 500 subjects in 2 years. At theend of the first year, 150 subjects have been enrolled. Monitoring reports from the first yearnote 50% of subjects screened were screen failures due to exclusionary lab values. Whataction should the sponsor take?
A. Re-train investigators on recruitment obligations.
B. Allocate additional monitoring resources to the trial.
C. Reduce the target sample size based on feedback from the sites.
D. Evaluate the screen failures to determine if the protocol needs revision.
Question # 10
Who ensures information regarding payments to subjects is documented in a writtenconsent form?
A. Coordinator
B. IRB/IEC
C. PI
D. Sponsor
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